Inbreeding and fertility in Irish Wolfhounds in Sweden: 1976 to 2007
نویسنده
چکیده
BACKGROUND Given that no influence of inbreeding on life expectancy could be demonstrated in Irish Wolfhounds in a previous study, it was decided to test the influence of inbreeding and other parameters on fertility in this breed. METHODS The study was based on all Irish Wolfhound litters registered in Sweden between 1976 and 2007 (n = 822 litters) as provided by the Swedish Kennel Club (SKK) and combined with a pedigree database going back to 1862. Analyses were performed using linear regression in a Generalised Linear Model and other tests in the SAS system. RESULTS Mean number of pups per litter was 6.01 +/- 2.65, with a maximum of 13. There were no significant differences in either the number of litters or the number of pups between years of birth. Males were used for breeding at a significantly earlier age than females. Mean number of litters per parent was 2.96 +/- 3.14 for males and 1.59 +/- 0.87 for females. No influence of Wright's inbreeding coefficients over 5, 10, 20 and 30 generations and/or Meuwissen's inbreeding coefficients on litter size was detected. In the Generalised Linear Model, highly significant, but weak (coefficient of determination (R2) = 0.0341) influences were found for maternal age at mating as well as maternal inbreeding measured by Wright's inbreeding coefficient over 30 generations and Meuwissen's inbreeding coefficient. Paternal inbreeding coefficients over 5, 10, 20 and 30 generations and calculated after Meuwissen, as well as maternal inbreeding coefficients over 5, 10 and 20 generations did not have significant effects on litter size. CONCLUSION The low coefficient of determination (R2) value of the Generalised Linear Model indicates that inbreeding does not have a strong influence on fertility in Irish Wolfhounds, which is consistent with earlier results and the breed's genetic history. These results likely reflect the aforementioned genetic history and should not be extrapolated to other breeds without prior breed-specific research.
منابع مشابه
Evaluation of tafazzin as candidate for dilated cardiomyopathy in Irish wolfhounds.
Dilated cardiomyopathy (DCM) is a common disease in humans and dogs. Large-breed dogs and especially Irish wolfhounds belong to the frequently affected breeds. Male Irish wolfhounds show a significantly higher prevalence of DCM than females. Therefore, we evaluated X chromosome markers for linkage with DCM as well as a human candidate gene on the X chromosome. A set of X chromosomal microsatell...
متن کاملAnalysis of the canine genome and canine health: a commentary.
The widespread consensus among biologists is that, with a few exceptions, inbreeding leads to a loss of biological fitness. Animals in an inbred lineage are less likely to survive and less likely to reproduce than animals in more outbred lineages. This has been demonstrated many times in well-studied, naturally outbreeding species. Inbreeding can result in reduced fertility both in litter size ...
متن کاملIndirect arterial blood pressure measurement in nonsedated Irish wolfhounds: reference values for the breed.
Arterial blood pressure measurements were obtained from 158 healthy Irish wolfhounds using the oscillometric technique to establish reference values for the breed. In contrast to other sight hounds, Irish wolfhounds have low arterial blood pressure. Mean systolic pressure for the group was 116.0 mm Hg. Mean diastolic pressure was 69.2 mm Hg, and the mean value for mean arterial pressure was 87....
متن کاملUse of echocardiography in the diagnosis of dilated cardiomyopathy in Irish wolfhounds.
The purpose of this study was to compare the echocardiographic features of Irish wolfhounds with clinically inapparent dilated cardiomyopathy (DCM) (n = 33) to dogs with advanced DCM (n = 33) and to normal dogs (n = 262). Significant differences were detected between the three groups. In dogs with DCM, the most sensitive diagnostic measurements were: end-systolic volume index (ESVI), E-point to...
متن کاملEchocardiographic measurements in the Irish wolfhound: reference values for the breed.
Out of 400 Irish wolfhounds cardiologically examined, echocardiographic measurements of 262 normal dogs were analyzed to obtain reference values for the breed. Based on regression analysis, several echocardiographic parameters showed significant linear correlation with body weight and with age, but coefficients of determination were low. Therefore, due to a high individual variability of echoca...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Acta Veterinaria Scandinavica
دوره 51 شماره
صفحات -
تاریخ انتشار 2009